Despite decades of research devoted to finding a vaccine against leishmaniasis, we are still
lacking a safe and effective vaccine for humans. Given this scenario, the search for a new …

Highlights•Intracellular amastigote stages of Leishmania activate a stringent metabolic
response.•The stringent response, triggered by H 2 O 2, involves extensive metabolic …

Malaria, caused by Plasmodium protozoal parasites, remains a leading cause of morbidity
and mortality. The Plasmodium parasite has a complex life cycle, with asexual and sexual …

Leishmania donovani relies on specific vitamins and cofactors crucial for its survival and
pathogenesis. Tailoring therapies to disrupt these pathways offers a promising strategy for …

Host-tissue preference is a critical aspect of parasitic infections and is directly correlated with
species diversity. Even the same species, Leishmania donovani, infects the host's bone …

The trace metal manganese in excess affects iron-sulfur cluster and heme-protein
biogenesis, eliciting cellular toxicity. The manganese efflux protein MntP is crucial to …

Glutamine Synthetase (GS) is functionally important in many pathogens, so its viability as a
drug target has been widely investigated. We identified Leishmania major glutamine …

The hexose monophosphate shunt is a crucial pathway in a variety of microorganisms owing
to its vital metabolic products and intermediates such as NADPH, ribose 5-phosphate etc …

Leishmaniasis is a parasitic and neglected tropical disease which majorly impacts poor and
developing nations. One of the significant factors that impacts the severity of the pathological …

Pyridoxal kinase (PdxK) is a vitamin B 6 salvage pathway enzyme which produces pyridoxal
phosphate. We have investigated the impact of PdxK deletion in Leishmania donovani on …