BACKGROUND: Practice guidelines reflect published literature. Because of the ever
changing literature base, it is necessary to update and revise guideline recommendations …

Objectives Perioperative bleeding is common among patients undergoing cardiac surgery;
however, the definition of perioperative bleeding is variable and lacks standardization. We …

Guidelines Management of severe peri-operative bleeding: Guidelines from the European
Society of Anaesthesiology and Intensive Care

Blood loss and subsequent transfusions are associated with major morbidity and mortality.
The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic …

Objectives We review the evidence for tranexamic acid (TXA) for the treatment and
prevention of bleeding caused by surgery, trauma and bleeding disorders. We highlight …

Fibrinolysis is a physiologic component of hemostasis that functions to limit clot formation.
However, following trauma or surgery excessive fibrinolysis may contribute to coagulopathy …

In the normal course of the delivery of care, anesthesiologists encounter many patients who
are receiving drugs that affect platelet function as a fundamental part of primary and …

Cardiopulmonary bypass (CPB) is a unique clinical scenario that results in widespread
activation of the hemostatic system. However, surgery also results in normal increases in …

Antifibrinolytic drugs have become almost ubiquitous in their use during major surgery when
bleeding is expected or commonplace. Inhibition of the fibrinolytic pathway after tissue injury …

Background: Acute kidney injury (AKI) after cardiac surgery is a major health issue. Two
important risk factors for AKI are preoperative anemia and perioperative erythrocyte …