Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers

Y Li, T Jiang, W Zhou, J Li, X Li, Q Wang, X Jin… - Nature …, 2020 - nature.com
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression
and they play fundamental roles in immune regulation. Here we introduce an integrated …

Gene regulation in the immune system by long noncoding RNAs

YG Chen, AT Satpathy, HY Chang - Nature immunology, 2017 - nature.com
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …

Global positioning system: understanding long noncoding RNAs through subcellular localization

J Carlevaro-Fita, R Johnson - Molecular cell, 2019 - cell.com
The localization of long noncoding RNAs (lncRNAs) within the cell is the primary
determinant of their molecular functions. LncRNAs are often thought of as chromatin …

A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis

B Liu, L Sun, Q Liu, C Gong, Y Yao, X Lv, L Lin, H Yao… - Cancer cell, 2015 - cell.com
NF-κB is a critical link between inflammation and cancer, but whether long non-coding RNAs
(lncRNAs) regulate its activation remains unknown. Here, we identify an NF-KappaB …

Immunobiology of long noncoding RNAs

MK Atianand, DR Caffrey… - Annual review of …, 2017 - annualreviews.org
The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene
regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that …

Long noncoding RNAs: past, present, and future

JTY Kung, D Colognori, JT Lee - Genetics, 2013 - academic.oup.com
Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

Long non-coding RNAs in the regulation of the immune response

JA Heward, MA Lindsay - Trends in immunology, 2014 - cell.com
It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological
responses, and that they do so by a diverse range of mechanisms. In the field of …

[HTML][HTML] Long non-coding RNAs: Mechanism of action and functional utility

SA Bhat, SM Ahmad, PT Mumtaz, AA Malik… - Non-coding RNA …, 2016 - Elsevier
Recent RNA sequencing studies have revealed that most of the human genome is
transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long …