The past several decades have witnessed great progress in “smart drug delivery”, an
advance technology that can deliver genes or drugs into specific locations of patients' body …

Sonoporation, or the use of ultrasound in the presence of cavitation nuclei to induce plasma
membrane perforation, is well considered as an emerging physical approach to facilitate the …

One factor critical to successful gene therapy is the development of efficient delivery
systems. Although advances in gene transfer technology, including viral and non-viral …

Despite the widespread use of sonication in medicine, industry, and research, the effects of
sonication on proteins remain poorly characterized. We report that sonication of a range of …

The development of ultrasound contrast agents, containing encapsulated microbubbles, has
increased the possibilities for diagnostic imaging. Ultrasound contrast agents are currently …

Liposome-based drug and gene delivery systems have potential for significant roles in a
variety of therapeutic applications. Recently, liposomes have been used to entrap gas and …

Ultrasound exposure (USE) in the presence of microbubbles (MCB)(eg contrast agents used
to enhance ultrasound imaging) increases plasmid transfection efficiency in vitro by several …

Over the last 5 years, physical methods of plasmid delivery have revolutionized the
efficiency of nonviral gene transfer, in some cases reaching the efficiencies of viral vectors …

More than 2 million bone-grafting procedures are performed each year using autografts or
allografts. However, both options carry disadvantages, and there remains a clear medical …

Microbubbles are used as ultrasonic contrast agents that enhance the ultrasound signals of
the vascular bed. The recent development of site-targeted microbubbles opened up the …