Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining
increased attention as they impose a considerable socioeconomic impact, due in part to the …

The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that
underpin relapse-associated and progressive disability. Disease mechanisms can be …

The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …

Metastasis to the brain is a leading cause of cancer mortality. The current diagnostic method
of gadolinium-enhanced MRI is sensitive only to larger tumors, when therapeutic options are …

Interest in nanoneuromedicine has grown rapidly due to the immediate need for improved
biomarkers and therapies for psychiatric, developmental, traumatic, inflammatory, infectious …

The goal of immunotherapy against autoimmunity is to block pathogenic inflammation
without impairing immunity against infections and tumours. Regulatory T-cells (Tregs) play a …

Sepsis-associated encephalopathy (SAE) refers to a clinical spectrum of acute neurological
dysfunction that arises in the context of sepsis. Although the pathophysiology of SAE is …

Endothelial cells of the central nervous system over-express surface proteins during
neurological disorders, either as a cause, or a consequence, of the disease. Since the …

Nuclear imaging is a powerful non-invasive imaging technique that is rapidly developing in
medical theranostics. Nuclear imaging requires radiolabeling isotopes for non-invasive …

Nanoparticulate carriers, often referred to as nanoparticles (NPs), represent an important
pharmacological advance for drug protection and tissue-specific drug delivery. Accessing …