[HTML][HTML] Understanding mechanisms of resistance to FLT3 inhibitors in adult FLT3-mutated Acute Myeloid Leukemia (AML) to guide treatment strategy
M Ruglioni, S Crucitta, GI Luculli, G Tancredi… - Critical Reviews in …, 2024 - Elsevier
The presence of FLT3 mutations, including the most common FLT3-ITD (internal tandem
duplications) and FLT3-TKD (tyrosine kinase domain), is associated with an unfavorable …
duplications) and FLT3-TKD (tyrosine kinase domain), is associated with an unfavorable …
[HTML][HTML] Leucemia promielocítica aguda. Estado del arte
L Mejía-Buriticá, JD Torres-Hernández, GJ Vásquez - Iatreia, 2021 - scielo.org.co
La leucemia promielocítica aguda (LPA) es un subtipo de leucemia mieloide aguda (LMA)
que se origina por una traslocación balanceada entre los cromosomas 15 y 17, involucra al …
que se origina por una traslocación balanceada entre los cromosomas 15 y 17, involucra al …
Acute promyelocytic leukemia with PML/RARA (bcr1, bcr2 and bcr3) transcripts in a pediatric patient
J Santana-Hernández, A Corona-Rivera… - Oncology …, 2024 - spandidos-publications.com
Patients with acute promyelocytic leukemia (APL) exhibit the t (15; 17)(q24. 1; q21. 2)
translocation that produces the promyelocytic leukemia (PML)/retinoic acid receptor α …
translocation that produces the promyelocytic leukemia (PML)/retinoic acid receptor α …
[HTML][HTML] Clinical analysis of 82 cases of acute promyelocytic leukemia with PML-RARα short isoform in children and adults
Q Huang, Y Zhang, M Zheng - Frontiers in Oncology, 2024 - frontiersin.org
Background Acute promyelocytic leukemia (APL) with PML/RARα fusion gene is a distinct
variant of acute myeloid leukemia. According to the different break sites of the PML gene …
variant of acute myeloid leukemia. According to the different break sites of the PML gene …
Favorable outcome of PML‐RARα short isoform and FLT3‐ITD mutation in a patient with several adverse prognostic markers: A case report
MA Bafail, R AlTahan, MA Samman… - Clinical Case …, 2023 - Wiley Online Library
Key Clinical Message Complete molecular remission in a “variant APL” patient with short
isoform of PML‐RARα and FLT3‐ITD mutation was achieved in response to ATRA and ATO …
isoform of PML‐RARα and FLT3‐ITD mutation was achieved in response to ATRA and ATO …
Impact of CD56 continuously recognizable as prognostic value of acute promyelocytic leukemia: results of multivariate analyses in the Japan adult leukemia study …
A Takeshita, N Asou, Y Atsuta, H Furumaki, T Sakura… - Cancers, 2020 - mdpi.com
Background: After long-term analysis of the JALSG-APL204 study we recently reported that
maintenance therapy with tamibarotene was more effective than all-trans retinoic acid …
maintenance therapy with tamibarotene was more effective than all-trans retinoic acid …
[HTML][HTML] No prognostic significance of normalized copy number of PML-RARA transcript at diagnosis in patients with acute promyelocytic leukemia
EO Rasekh, GM Elsayed, S Fathy - Hematology/Oncology and Stem Cell …, 2021 - Elsevier
Background Acute promyelocytic leukemia is a peculiar disease with few studies that have
investigated the prognostic significance of PML/RARA transcript level at diagnosis. Patients …
investigated the prognostic significance of PML/RARA transcript level at diagnosis. Patients …
[HTML][HTML] Different Isoforms of PML-RARA Chimeric Protein in Patients with Acute Promyelocytic Leukemia: Survival Analysis per Demographic Characteristics …
S Siahbani, A Safaei, M Faghih… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Methods: We included 145 consecutive eligible patients in this study. Data were collected
through archived documents and phone inquiries, following consent. Subsequently, we …
through archived documents and phone inquiries, following consent. Subsequently, we …
All-trans retinoic acid, arsenic trioxide, and anthracycline-based chemotherapy improves outcome in newly diagnosed acute promyelocytic leukemia regardless of …
L Xu, Y Su, H Tao - Current Medical Science, 2021 - Springer
All-trans retinoic acid (ATRA) and pre-upfront arsenic trioxide (ATO) have revolutionized the
therapy of acute promyelocytic leukemia (APL). However, internal tandem duplication of …
therapy of acute promyelocytic leukemia (APL). However, internal tandem duplication of …
FLT3-ITD mutation does not influence survival outcome in adult acute promyelocytic leukemia patients treated with ATO and ATRA-based therapeutic regimen …
RR Deka, S Naseem, P Bhatia, J Binota… - … Myeloma and Leukemia, 2022 - Elsevier
Abstract Introduction NPM1 and FLT3-ITD are frequently mutated genes in acute myeloid
leukemia. We studied clinico-hematological profile and survival outcome of adult acute …
leukemia. We studied clinico-hematological profile and survival outcome of adult acute …