Importance Recent clinical and imaging studies underscore that major adverse cardiac
events (MACE) outcomes are associated not solely with severe coronary obstructions …

Cardiovascular diseases are the leading cause of death around the world. Despite the
larger number of genes and loci identified, the precise mechanisms by which these genes …

Elevated hematocrit is associated with cardiovascular risk; however, the causality and
mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases cardiovascular risk …

Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages:
initiation, progression (or regression), and complications. By integrating known biology …

BACKGROUND: Using proteomics, we aimed to reveal molecular types of human
atherosclerotic lesions and study their associations with histology, imaging, and …

Heme is one of the most abundant molecules in the body acting as the functional core of
hemoglobin/myoglobin involved in the O2/CO2 carrying in the blood and tissues, redox …

Background While single‐omics analyses on human atherosclerotic plaque have been very
useful to map stage‐or disease‐related differences in expression, they only partly capture …

Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious
short-and long-term complications. In clinical practice, there is a need for improved plasma …

Aims Inflammatory mediators, including blood cells and their products, contribute critically to
atherogenesis, but the igniting triggers of inflammation remain elusive. Atherosclerosis …

Background Metabolism is increasingly recognized as a key regulator of the function and
phenotype of the primary cellular constituents of the atherosclerotic vascular wall, including …