Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

CR Sagandira, S Nqeketo, K Mhlana, T Sonti… - Reaction Chemistry & …, 2022 - pubs.rsc.org
Continuous flow chemistry has opened a new paradigm in both the laboratory and
pharmaceutical industry. This review details the recently reported literature on continuous …

Application of reactor engineering concepts in continuous flow chemistry: a review

NC Neyt, DL Riley - Reaction Chemistry & Engineering, 2021 - pubs.rsc.org
The adoption of flow technology for the manufacture of chemical entities, and in particular
pharmaceuticals, has seen rapid growth over the past two decades with the technology now …

Analytical tools integrated in continuous-flow reactors: which one for what?

M Rodriguez-Zubiri, FX Felpin - Organic Process Research & …, 2022 - ACS Publications
The concept and practices of chemical synthesis are being profoundly transformed toward
the development of fully autonomous continuous processes. Critical to the development of …

From circular synthesis to material manufacturing: advances, challenges, and future steps for using flow chemistry in novel application area

A Sivo, R de Souza Galaverna, GR Gomes… - Reaction Chemistry & …, 2021 - pubs.rsc.org
Continuous-flow technologies are becoming increasingly relevant in the chemistry field. The
vast arrays of reactor design, in terms of structural geometry, mixing, and residence time, the …

1, 3‐Dipolar Cycloaddition Reactions of Nitrile Oxides under “Non‐Conventional” Conditions: Green Solvents, Irradiation, and Continuous Flow

J Plumet - ChemPlusChem, 2020 - Wiley Online Library
Abstract The 1, 3‐dipolar cycloaddition reactions (DCs) of nitrile oxides (NOs) to alkenes
and alkynes are useful methods for the synthesis of 2‐isoxazolines and isoxazoles …

One-flow synthesis of tetrahydrocannabinol and cannabidiol using homo-and heterogeneous Lewis acids

VRLJ Bloemendal, B Spierenburg, TJ Boltje… - Journal of Flow …, 2021 - Springer
Continuous flow chemistry holds great potential for the production of biologically relevant
molecules. Herein, we present an approach for the continuous synthesis of cannabidiol and …

Advances in frontiers of organic synthesis in microreactor

J ZHANG, Y ZHOU, Z CHEN, J XU - CIESC Journal, 2022 - hgxb.cip.com.cn
Microreactor generally refers to microreactor with characteristic size ranging from microns to
hundreds of microns and is one of the core equipment of microchemical systems. Compared …

[图书][B] Flow Chemistry–Applications

J Alcázar, E Alvarez, A Anastasopoulou, Á Bódis… - 2021 - books.google.com
The fully up-dated edition of the two-volume work covers both the theoretical foundation as
well as the practical aspects. A strong insight in driving a chemical reaction is crucial for a …

11 Outlook, future directions, and emerging applications

SV Ley, OS May, OM Griffiths, K Sowa - Flow Chemistry–Applications, 2021 - degruyter.com
The preceding chapters in this second edition make a compelling case for the application of
flow chemistry and its related technologies. Its many innovations over the last 20 years have …

Flow chemistry development in the synthesis of pharmaceutical products, the example of Domperidone and related compounds

C Gennaro - 2021 - tesidottorato.depositolegale.it
The flow synthesis of Domperidone and some structurally related analogues was
approached using a statistical approach (DoE) to maximize the product conversion …