Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …

Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

According to current dogma, chondrocytes and osteoblasts are considered independent
lineages derived from a common osteochondroprogenitor. In endochondral bone formation …

SOX9 is a pivotal transcription factor in chondrocytes, a lineage essential in skeletogenesis.
Its mandatory role in transactivating many cartilage-specific genes is well established …

Genetics in model organisms has progressively broken down walls that previously
separated different disciplines of biology. One example of this holistic evolution is the …

One of the crucial steps in endochondral bone formation is the replacement of a cartilage
matrix produced by chondrocytes with bone trabeculae made by osteoblasts. However, the …

Tissue stem cells contribute to tissue regeneration and wound repair through cellular
programs that can be hijacked by cancer cells. Here, we investigate such a phenomenon in …

The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …