Cytokine storm in COVID-19: immunopathogenesis and therapy
C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
A cytokine storm is a hyperinflammatory state secondary to the excessive production of
cytokines by a deregulated immune system. It manifests clinically as an influenza-like …
cytokines by a deregulated immune system. It manifests clinically as an influenza-like …
Juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) is an umbrella term for arthritis of unknown origin, lasting
for> 6 weeks with onset before 16 years of age. JIA is the most common chronic …
for> 6 weeks with onset before 16 years of age. JIA is the most common chronic …
Cytokine storm
DC Fajgenbaum, CH June - New England Journal of Medicine, 2020 - Mass Medical Soc
Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …
immune-cell hyperactivation, has various causes and is characterized by constitutional …
Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment
COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes
only mild symptoms in the majority of the cases, while immunologic complications such as …
only mild symptoms in the majority of the cases, while immunologic complications such as …
The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease
Severe COVID-19 associated pneumonia patients may exhibit features of systemic hyper-
inflammation designated under the umbrella term of macrophage activation syndrome …
inflammation designated under the umbrella term of macrophage activation syndrome …
Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
Thrombosis in COVID‐19
Thrombotic complications are frequent in COVID‐19 and contribute significantly to mortality
and morbidity. We review several mechanisms of hypercoagulability in sepsis that may be …
and morbidity. We review several mechanisms of hypercoagulability in sepsis that may be …
COVID-19, immune system response, hyperinflammation and repurposingantirheumatic drugs
Abstract In the Wuhan Province of China, in December 2019, the novel coronavirus 2019
(COVID-19) has caused a severe involvement of the lower respiratory tract leading to an …
(COVID-19) has caused a severe involvement of the lower respiratory tract leading to an …
Cytokine release syndrome in severe COVID-19
In December 2019, a new strain of coronavirus, severe acute respiratory syndrome–
coronavirus 2 (SARS-CoV-2), was recognized to have emerged in Wuhan, China. Along …
coronavirus 2 (SARS-CoV-2), was recognized to have emerged in Wuhan, China. Along …
Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial
Y Cao, J Wei, L Zou, T Jiang, G Wang, L Chen… - Journal of Allergy and …, 2020 - Elsevier
Background Accumulating evidence proposed Janus-associated kinase (JAK) inhibitors as
therapeutic targets warranting rapid investigation. Objective This study evaluated the …
therapeutic targets warranting rapid investigation. Objective This study evaluated the …