Recent advances in predicting protein–protein interactions with the aid of artificial intelligence algorithms

S Li, S Wu, L Wang, F Li, H Jiang, F Bai - Current Opinion in Structural …, 2022 - Elsevier
Protein–protein interactions (PPIs) are essential in the regulation of biological functions and
cell events, therefore understanding PPIs have become a key issue to understanding the …

Integrating multi-omics to unravel host-microbiome interactions in inflammatory bowel disease

Y Zhang, JP Thomas, T Korcsmaros, L Gul - Cell Reports Medicine, 2024 - cell.com
The gut microbiome is crucial for nutrient metabolism, immune regulation, and intestinal
homeostasis with changes in its composition linked to complex diseases like inflammatory …

HPIDB 2.0: a curated database for host–pathogen interactions

MG Ammari, CR Gresham, FM McCarthy, B Nanduri - Database, 2016 - academic.oup.com
Identification and analysis of host–pathogen interactions (HPI) is essential to study infectious
diseases. However, HPI data are sparse in existing molecular interaction databases …

HVIDB: a comprehensive database for human–virus protein–protein interactions

X Yang, X Lian, C Fu, S Wuchty, S Yang… - Briefings in …, 2021 - academic.oup.com
While leading to millions of people's deaths every year the treatment of viral infectious
diseases remains a huge public health challenge. Therefore, an in-depth understanding of …

Transfer learning via multi-scale convolutional neural layers for human–virus protein–protein interaction prediction

X Yang, S Yang, X Lian, S Wuchty, Z Zhang - Bioinformatics, 2021 - academic.oup.com
Motivation To complement experimental efforts, machine learning-based computational
methods are playing an increasingly important role to predict human–virus protein–protein …

A review on computational systems biology of pathogen–host interactions

S Durmuş, T Çakır, A Özgür, R Guthke - Frontiers in microbiology, 2015 - frontiersin.org
Pathogens manipulate the cellular mechanisms of host organisms via pathogen–host
interactions (PHIs) in order to take advantage of the capabilities of host cells, leading to …

Computational approaches for prediction of pathogen-host protein-protein interactions

E Nourani, F Khunjush, S Durmuş - Frontiers in microbiology, 2015 - frontiersin.org
Infectious diseases are still among the major and prevalent health problems, mostly
because of the drug resistance of novel variants of pathogens. Molecular interactions …

Artificial intelligence applications in the diagnosis and treatment of bacterial infections

X Zhang, D Zhang, X Zhang, X Zhang - Frontiers in Microbiology, 2024 - frontiersin.org
The diagnosis and treatment of bacterial infections in the medical and public health field in
the 21st century remain significantly challenging. Artificial Intelligence (AI) has emerged as a …

Dissection of hubs and bottlenecks in a protein-protein interaction network

C Nithya, M Kiran, HA Nagarajaram - Computational Biology and …, 2023 - Elsevier
Abstract Analysis of degree centrality in conjunction with betweenness centrality of proteins
in a human protein-protein interaction network revealed three categories of centrally …

Network representations of immune system complexity

N Subramanian, P Torabi‐Parizi… - … Systems Biology and …, 2015 - Wiley Online Library
The mammalian immune system is a dynamic multiscale system composed of a
hierarchically organized set of molecular, cellular, and organismal networks that act in …