Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Multiple sclerosis (MS) is a frequent autoimmune demyelinating disease of the central
nervous system (CNS). There are three clinical forms described: relapsing-remitting multiple …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) in which the immune system damages the protective insulation surrounding the nerve …

Multiple sclerosis (MS) is a disabling disease of the CNS. Inflammatory features of MS
include lymphocyte accumulations in the CNS and cerebrospinal fluid (CSF). The preclinical …

T cells are considered pivotal in the pathology of multiple sclerosis (MS), but their function
and antigen specificity are unknown. To unravel the role of T cells in MS pathology, we …

Phosphodiesterases (PDE) are a diverse family of enzymes (11 isoforms so far identified)
responsible for the degradation of cyclic adenosine monophosphate (cAMP) and cyclic …

The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Adaptive immune response is part of the dynamic changes that accompany motoneuron loss
in amyotrophic lateral sclerosis (ALS). CD4+ T cells that regulate a protective immunity …

Neurodegenerative diseases are closely related to inflammatory and autoimmune events,
suggesting that the dysregulation of the immune system is a key pathological factor. Both …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …