Around 11% of all known gene lesions causing human genetic diseases are nonsense
mutations that introduce a premature stop codon (PTC) into the protein-coding gene …

Blindness poses a growing global challenge, with approximately 26% of cases attributed to
degenerative retinal diseases. While gene therapy, optogenetic tools, photosensitive …

There is an emblematic clinical and genetic heterogeneity associated with inherited retinal
diseases (IRDs). The most common form is retinitis pigmentosa (RP), a rod-cone dystrophy …

Nonsense mutations trigger premature translation termination and often give rise to
prevalent and rare genetic diseases. Consequently, the pharmacological suppression of an …

Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) is expressed in photoreceptors
where it facilitates the assembly of phosphodiesterase 6 (PDE6) which hydrolyses cGMP …

Inherited retinal diseases (IRDs) represent a diverse group of genetic disorders leading to
progressive degeneration of the retina due to mutations in over 280 genes. This review …

Synthetic or natural small molecules have been extensively employed as trigger signals or
inducers to regulate engineered gene circuits introduced into living cells in order to obtain …

Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration
and impose a considerable economic burden on patients and society, making efforts to cure …

Human embryonic stem cells (hESCs)-and induced pluripotent stem cells (hiPSCs)-derived
retinal organoids (ROs) are three-dimensional laminar structures that recapitulate the …

The eyes are one of the most important sensory organs in the human body. Currently,
diseases such as limbal stem cell deficiency, cataract, retinitis pigmentosa and dry eye …