The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …

Gluconeogenesis is a critical biosynthetic process that helps maintain whole-body glucose
homeostasis and becomes altered in certain medical diseases. We review gluconeogenic …

Whether amino acids act on cellular insulin signaling remains unclear, given that increased
circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here …

Nicotinamide mononucleotide (NNM) is an orally bioavailable NAD+ precursor that has
demonstrated beneficial effects against aging and aging-associated diseases in animal …

Background: Diet manipulation is the basis for prevention of obesity and diabetes. The
molecular mechanisms that mediate the diet-based prevention of insulin resistance are not …

Obesity is associated with an increased risk of insulin resistance (IR) and type 2 diabetes
mellitus (T2DM) which is a multi-factorial disease associated with a dysregulated …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

The most frequent alterations in plasma amino acid concentrations in type 1 and type 2
diabetes are decreased L-serine and increased branched-chain amino acid (BCAA; valine …

Diabetes mellitus, a disease of modern civilization, is considered the major mainstay of
mortalities around the globe. A great number of biochemical changes have been proposed …

Chronic low-grade metabolic acidosis is now a common phenomenon in the Western world.
The high dietary intake of sulfur-containing amino acids in the form of processed meats …