[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
A guide to complement biology, pathology and therapeutic opportunity
DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
Drug treatment of COVID-19 infection
G Lui, G Guaraldi - Current Opinion in Pulmonary Medicine, 2023 - journals.lww.com
Drug treatment of COVID-19 infection : Current Opinion in Pulmonary Medicine Drug treatment
of COVID-19 infection : Current Opinion in Pulmonary Medicine Log in or Register Subscribe to …
of COVID-19 infection : Current Opinion in Pulmonary Medicine Log in or Register Subscribe to …
COVID-19: An Update on the Latest Therapeutic Agents
The COVID-19 pandemic has plagued the world for over three years since discovering the
causative virus, SARS-CoV-2, in China. The rampant spread of the virus led to the loss of …
causative virus, SARS-CoV-2, in China. The rampant spread of the virus led to the loss of …
A complement atlas identifies interleukin-6–dependent alternative pathway dysregulation as a key druggable feature of COVID-19
KFA Van Damme, L Hoste, J Declercq… - Science Translational …, 2023 - science.org
Improvements in COVID-19 treatments, especially for the critically ill, require deeper
understanding of the mechanisms driving disease pathology. The complement system is not …
understanding of the mechanisms driving disease pathology. The complement system is not …
COVID-19 drug discovery and treatment options
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …
[HTML][HTML] C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps
Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that
may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that …
may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that …
[HTML][HTML] Recent advances in monoclonal antibody-based approaches in the management of bacterial sepsis
K Kharga, L Kumar, SKS Patel - Biomedicines, 2023 - mdpi.com
Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …
response to an infectious agent and its antigens. Immune cell activation against the antigens …
Emerging role of monoclonal antibodies in the treatment of IgA nephropathy
D Maixnerova, V Tesar - Expert Opinion on Biological Therapy, 2023 - Taylor & Francis
Introduction IgA nephropathy is the most common primary glomerulonephritis worldwide.
Immune complexes, composed of galactose-deficient IgA1 and Gd-IgA1 autoantibodies, are …
Immune complexes, composed of galactose-deficient IgA1 and Gd-IgA1 autoantibodies, are …
[PDF][PDF] Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors
The complement system is a critical part of our innate immune response, and the terminal
products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and …
products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and …