Conspectus Peptides are essential components of living systems and contribute to critical
biological processes, such as cell proliferation, immune defense, tumor formation, and …

Binding of one protein to another is involved in nearly all biological functions, yet the
principles governing the interaction of proteins are not fully understood. To analyze the …

Most proteins assemble into multisubunit complexes. The persistence of these complexes
across evolutionary time is usually explained as the result of natural selection for functional …

The recognition of specific DNA sequences by proteins is thought to depend on two types of
mechanism: one that involves the formation of hydrogen bonds with specific bases, primarily …

Absolute binding free energy calculations and free energy decompositions are presented for
the protein–protein complexes H-Ras/C-Raf1 and H-Ras/RalGDS. Ras is a central switch in …

The docking field has come of age. The time is ripe to present the principles of docking,
reviewing the current state of the field. Two reasons are largely responsible for the maturity …

Several sequence and structural factors have been proposed to contribute toward greater
stability of thermophilic proteins. Here we present a statistical examination of structural and …

Therapeutic proteins such as antibodies constitute the most rapidly growing class of
pharmaceuticals for use in diverse clinical settings including cancer, chronic inflammatory …

Proteins are the working horse of the cellular machinery. They are responsible for diverse
functions ranging from molecular motors to signaling. They catalyze reactions, transport …

Structural and mutational analyses reveal a central role for electrostatic interactions in
protein–protein association. Experiment and theory both demonstrate that clusters of …