Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

A. Genetic, molecular, and transgenic models B. Human GH rhythms III. Neuropeptide
Regulation of the GH Axis: Somatostatin and GHRH

The secretion of growth hormone (GH) is regulated through a complex neuroendocrine
control system, especially by the functional interplay of two hypothalamic hypophysiotropic …

Since the discovery of somatostatin (SST) over three decades ago, its ubiquitous distribution
and manifold functions are still being documented. SST is synthesized in the hypothalamus …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

GH-releasing peptides (GHRPs), a class of small synthetic peptide and non-peptide
compounds, act on specific receptors at both the pituitary and the hypothalamic level to …

Background Acromegaly is a rare disease characterized by a chronic exposition to growth
hormone (GH) and insulin-like growth factor-1 (IGF-1), caused in most cases by a pituitary …

Growth hormone (GH) plays a key role not only in the promotion of linear growth but also in
the regulation of intermediary metabolism, body composition, and energy expenditure. On …

We here investigate the potential rescue of the relative hyposomatotropism of aging and
obesity by 3-day pulsatile GHRH infusions (iv bolus 0.33 microg/kg every 90 min) in 19 …

Testosterone (T) is known to affect the growth hormone (GH) axis. However, the
mechanisms underlying the activation of GH secretion by T still remain to be clarified …