Potassium-dependent sodium-calcium exchangers (NCKX) have emerged as key
determinants of calcium (Ca2+) signaling and homeostasis, especially in environments …

Biomineralization requires the controlled movement of ions across cell barriers to reach the
sites of crystal growth. Mineral precipitation occurs in aqueous phases as fluids become …

Inflammatory bowel diseases (IBDs) comprises a range of chronic inflammatory conditions of
the intestinal tract. The incidence and prevalence of IBDs are increasing worldwide, but the …

TRPM7 plays an important role in cellular Ca2+, Zn2+ and Mg2+ homeostasis. TRPM7
channels are abundantly expressed in ameloblasts and, in the absence of TRPM7, dental …

Objectives In order to understand the specific in vivo function of transforming growth factor-
beta1 (TGF-β1), we successfully established aTGF-β1 deficient mouse model using a …

Enamel formation (amelogenesis) is a two-step process whereby crystals partially grow
during the secretory stage followed by a significant growth expansion during the maturation …

Most cells use calcium (Ca2+) as a second messenger to convey signals that affect a
multitude of biological processes. The ability of Ca2+ to bind to proteins to alter their charge …

Calcium (Ca2+) extrusion is an essential function of the enamel-forming ameloblasts,
providing Ca2+ for extracellular mineralization. The plasma membrane Ca2+ ATPases …

The formation of dentin and enamel matrix depends on reciprocal interactions between
epithelial-mesenchymal cells. To assess the role of mitochondrial function in amelogenesis …

Enamel development is a process in which extracellular matrix models from a soft
proteinaceous matrix to the most mineralized tissue in vertebrates. Patients with mutant …