There is a growing appreciation that the regulation of the melatonergic pathways, both
pineal and systemic, may be an important aspect in how viruses drive the cellular changes …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

This Opinion article discusses emerging evidence of direct contributions of nicotine to
cancer onset and growth. The list of cancers reportedly connected to nicotine is expanding …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

The mammalian immune system and the nervous system coevolved under the influence of
cellular and environmental stress. Cellular stress is associated with changes in immunity …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Neurons coordinate inter-tissue protein homeostasis to systemically manage cytotoxic
stress. In response to neuronal mitochondrial stress, specific neuronal signals coordinate …

Neutrophils are peripheral immune cells that represent the first recruited innate immune
defense against infections and tissue injury. However, these cells can also induce …

Besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the
brains of patients with Alzheimer's disease (AD), the pathogenesis of AD is also thought to …

Mitochondria are multifunctional and dynamic organelles deeply integrated into cellular
physiology and metabolism. Disturbances in mitochondrial function are involved in several …