Advances in computational methods to discover new NS2B-NS3 inhibitors useful against dengue and Zika viruses

IJ dos Santos Nascimento… - Current Topics in …, 2022 - ingentaconnect.com
The Flaviviridae virus family consists of the genera Hepacivirus, Pestivirus, and Flavivirus,
with approximately 70 viral types that use arthropods as vectors. Among these diseases …

[HTML][HTML] Transactivation domain of Adenovirus Early Region 1A (E1A): Investigating folding dynamics and aggregation

N Sharma, K Gadhave, P Kumar, R Giri - Current Research in Structural …, 2022 - Elsevier
Abstract Transactivation domain of Adenovirus Early region 1A (E1A) oncoprotein is an
intrinsically disordered molecular hub protein. It is involved in binding to different domains of …

Differentially Labeled Flaviviral Protease-cofactor Complex for NMR Spectroscopic Applications

A Kumar - Protein Expression and Purification, 2025 - Elsevier
Abstract Flaviviruses such as Dengue, Zika and West-Nile viruses have a positive strand
RNA genome which is translated to a polyprotein inside the host cell. The viral polypeptide …

[HTML][HTML] Investigating the folding dynamics of NS2B protein of Zika virus

A Kumar, P Kumar, PM Mishra, R Giri - Virology, 2023 - Elsevier
NS2B protein of the Zika virus acts as a co-factor for NS3 protease and also involves in
remodeling NS3 protease structure. Therefore, we investigated the overall dynamics of …

Discovery And Characterization of Small Molecule Inhibitors of Zika Virus Replication

A Kumar, D Kumar, P Kumar, BL Jones, IU Mysorekar… - bioRxiv, 2022 - biorxiv.org
Zika virus (ZIKV) is a flavivirus, and ZIKV infections in the past 15 years have been linked to
Guillain-Barre syndrome and severe complications during pregnancy associated with …

[图书][B] Virus-Host Cell Interactions Modulating the Pathogenesis of ZIKV In Vitro

IMN Bird - 2021 - search.proquest.com
Abstract The reemergence of Zika Virus (ZIKV) isolates that result in severe neuropathology
has elevated ZIKV into a major concern for global health following outbreaks in French …