Nuclear physics in particle therapy: a review

M Durante, H Paganetti - Reports on Progress in Physics, 2016 - iopscience.iop.org
Charged particle therapy has been largely driven and influenced by nuclear physics. The
increase in energy deposition density along the ion path in the body allows reducing the …

The national centre for oncological hadrontherapy (CNAO): status and perspectives

S Rossi - Physica Medica, 2015 - Elsevier
Abstract The National Centre for Oncological Hadrontherapy (CNAO, sited in Pavia, Italy)
completed at the end of 2013 the clinical trial phase achieving the CE label from the notified …

First clinical application of a prompt gamma based in vivo proton range verification system

C Richter, G Pausch, S Barczyk, M Priegnitz… - Radiotherapy and …, 2016 - Elsevier
Background and purpose To improve precision of particle therapy, in vivo range verification
is highly desirable. Methods based on prompt gamma rays emitted during treatment seem …

[HTML][HTML] Evaluation of stopping-power prediction by dual-and single-energy computed tomography in an anthropomorphic ground-truth phantom

P Wohlfahrt, C Möhler, C Richter, S Greilich - International Journal of …, 2018 - Elsevier
Purpose To determine the accuracy of particle range prediction for proton and heavier ion
radiation therapy based on dual-energy computed tomography (DECT) in a realistic …

Dual-energy CT based proton range prediction in head and pelvic tumor patients

P Wohlfahrt, C Möhler, K Stützer, S Greilich… - Radiotherapy and …, 2017 - Elsevier
Background and purpose To reduce range uncertainty in particle therapy, an accurate
computation of stopping-power ratios (SPRs) based on computed tomography (CT) is …

Inter-fractional monitoring of C ions treatments: results from a clinical trial at the CNAO facility

M Fischetti, G Baroni, G Battistoni, G Bisogni… - Scientific Reports, 2020 - nature.com
The high dose conformity and healthy tissue sparing achievable in Particle Therapy when
using C ions calls for safety factors in treatment planning, to prevent the tumor under-dosage …

Experimental validation of a 4D dose calculation routine for pencil beam scanning proton therapy

T Pfeiler, C Bäumer, E Engwall, D Geismar… - … für Medizinische Physik, 2018 - Elsevier
Respiratory induced organ motion poses a major challenge for high-precision radiotherapy
such as pencil beam scanning proton therapy (PBS). In order to employ PBS for target …

Sensitivity of a prompt-gamma slit-camera to detect range shifts for proton treatment verification

L Nenoff, M Priegnitz, G Janssens, J Petzoldt… - Radiotherapy and …, 2017 - Elsevier
Background and purpose A prompt-gamma imaging (PGI) slit-camera was recently applied
successfully in clinical proton treatments using pencil beam scanning (PBS) and double …

Dual-energy computed tomography to assess intra-and inter-patient tissue variability for proton treatment planning of patients with brain tumor

P Wohlfahrt, C Möhler, EGC Troost, S Greilich… - International Journal of …, 2019 - Elsevier
Purpose Range prediction in particle therapy is associated with an uncertainty originating
from calculating the stopping-power ratio (SPR) based on x-ray computed tomography (CT) …

Refinement of the Hounsfield look‐up table by retrospective application of patient‐specific direct proton stopping‐power prediction from dual‐energy CT

P Wohlfahrt, C Möhler, W Enghardt, M Krause… - Medical …, 2020 - Wiley Online Library
Background and Purpose Proton treatment planning relies on an accurate determination of
stopping‐power ratio (SPR) from x‐ray computed tomography (CT). A refinement of the …