Alzheimer’s disease as a chronic maladaptive polyamine stress response - PMC Back to Top
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Tau, a microtubule-associated protein predominantly localized in neuronal axons, plays a
crucial role in promoting microtubule assembly, stabilizing their structure, and participating …

Innate immune activation is a major contributor to Alzheimer's Disease (AD)
pathophysiology, although the mechanisms involved are poorly understood. Chemokine CC …

Ectotherms have peculiar relationships with microorganisms. For instance, bacteria are
recovered from the blood and internal organs of healthy teleosts. However, the presence of …

Aging is the most prominent risk factor for neurodegeneration occurrence. The most
common neurodegenerative diseases (NDs), Alzheimer's (AD) and Parkinson's (PD) …

Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral
impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral …

Liquid-liquid phase separation (LLPS) is currently recognized as a common mechanism
involved in the regulation of a number of cellular functions. On the other hand, aberrant …

Abnormal tau build-up is a hallmark of Alzheimer's disease (AD) and more than 20 other
serious neurodegenerative diseases. Mitochondria are paramount organelles playing a …

Alzheimer's disease (AD) is a neurodegenerative disorder that commonly occurs among
older individuals. Increasing evidence suggests that a low-caloric diet might be a promising …

Tauopathies and synucleinopathies are characterized by the aggregation of Tau and α-
synuclein (AS) into amyloid structures, respectively. Individuals with these neuropathies …