Metabolomic and lipidomic biomarkers for premalignant liver disease diagnosis and therapy
In recent years, there has been a plethora of attempts to discover biomarkers that are more
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …
Metabolic rewiring and the characterization of oncometabolites
Simple Summary Oncometabolites are produced by cancer cells and assist the cancer to
proliferate and progress. Oncometabolites occur as a result of mutated enzymes in the tumor …
proliferate and progress. Oncometabolites occur as a result of mutated enzymes in the tumor …
Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis
We wished to understand the metabolic reprogramming underlying liver fibrosis progression
in mice. Administration to male C57BL/6J mice of the hepatotoxins carbon tetrachloride …
in mice. Administration to male C57BL/6J mice of the hepatotoxins carbon tetrachloride …
Addition of grapes to both a standard and a high-fat Western pattern diet modifies hepatic and urinary metabolite profiles in the mouse
The benefits of fruit and vegetable dietary consumption are largely defined in
epidemiological terms. Relatively little is known about the discrete effects on metabolic …
epidemiological terms. Relatively little is known about the discrete effects on metabolic …
Metabolomic insights into the mode of action of natural products in the treatment of liver disease
The human population is burdened by morbidity and mortality from liver diseases that
largely arise due to hepatitis virus infection, alcohol abuse, obesity, and diabetes. Despite 2 …
largely arise due to hepatitis virus infection, alcohol abuse, obesity, and diabetes. Despite 2 …
A Metabolomic Analysis of Cirrhotic Ascites
Ascites is a common complication of decompensated liver cirrhosis, and yet relatively little is
known about its biochemical composition. We conducted two metabolomic investigations …
known about its biochemical composition. We conducted two metabolomic investigations …
Metabolomics in Parkinson's disease
Parkinson's disease (PD) is a multifactorial neurodegenerative disorder in which
environmental (lifestyle, dietary, infectious disease) factors as well as genetic make-up play …
environmental (lifestyle, dietary, infectious disease) factors as well as genetic make-up play …
Research and development of anticancer agents under the guidance of biomarkers
X Xu, G Qiu, L Ji, R Ma, Z Dang, R Jia… - Cancer Translational …, 2019 - search.proquest.com
At present, cancer ranks first as the cause of death in the world, necessitating the need to
develop new anticancer agents. As a probe, biomarkers can indicate the biological and …
develop new anticancer agents. As a probe, biomarkers can indicate the biological and …
(2R,3S)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid Leukemia
Simple Summary Acute myeloid leukemia (AML) is one of several cancers where cancer
proliferation occurs under the influence of an aberrant metabolite known as an …
proliferation occurs under the influence of an aberrant metabolite known as an …
Compound Identification Strategies in Mass Spectrometry-Based Metabolomics and Pharmacometabolomics
The metabolome is composed of a vast array of molecules, including endogenous
metabolites and lipids, diet-and microbiome-derived substances, pharmaceuticals and …
metabolites and lipids, diet-and microbiome-derived substances, pharmaceuticals and …