Nuclear magnetic resonance (NMR) spectroscopy has contributed to structure-based drug development (SBDD) in a unique way compared to the other biophysical methods. The …
The past decade has witnessed remarkable progress in the determination of G protein- coupled receptor (GPCR) structures, profoundly expanding our understanding of how …
Escherichia coli (E. coli) is the most widely used expression host for recombinant proteins due to high expression yields and straightforward molecular cloning. Directed evolution of G …
DK Weber, T Bader, EK Larsen, S Wang… - Methods in …, 2019 - Elsevier
Solid-state NMR (ssNMR) is an ideal tool to study structure and dynamics of membrane proteins in their native lipid environment. In principle, ssNMR has no size limitations …
The dynamic property of a ligand in the receptor-bound state is an important metric to characterize the interactions in the ligand–receptor interface, and the development of an …
The Ca 2+ transient of the cardiomyocyte is key to the contractility of the heart. Its dysregulation has been associated with heart disease, leading to investigation of the …
Abstract G Protein-Coupled Receptors (GPCRs) deliver approximately 80% of all signals across the cell membrane and are targets for around 26% of all prescription drugs …