Plant‐derived vesicle‐like nanoparticles as promising biotherapeutic tools: Present and future

J Feng, Q Xiu, Y Huang, Z Troyer, B Li… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are heterogeneous, phospholipid bilayer‐enclosed biological
particles that regulate cell communication by molecular cargo delivery and surface …

Advances in exosome-based drug delivery and tumor targeting: from tissue distribution to intracellular fate

J Shao, J Zaro, Y Shen - International journal of nanomedicine, 2020 - Taylor & Francis
Exosomes or small extracellular vesicles are considered a new generation of bioinspired-
nanoscale drug delivery system (DDS). Endogenous exosomes function as signalosomes …

High-quality milk exosomes as oral drug delivery system

J Zhong, B Xia, S Shan, A Zheng, S Zhang, J Chen… - Biomaterials, 2021 - Elsevier
Many drugs must be administered intravenously instead of oral administration due to their
poor oral bioavailability. The cost of repeated infusion treatment for 6 weeks every year is as …

[HTML][HTML] Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

S Manca, B Upadhyaya, E Mutai, AT Desaulniers… - Scientific reports, 2018 - nature.com
Exosomes participate in cell-to-cell communication, facilitated by the transfer of RNAs,
proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not …

[HTML][HTML] Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model

SC Guo, SC Tao, WJ Yin, X Qi, T Yuan, CQ Zhang - Theranostics, 2017 - ncbi.nlm.nih.gov
Chronic wounds have become an economic, social, and public health burden and need
advanced treatment. Platelet-rich plasma (PRP) has been used extensively in treatment of …

[HTML][HTML] Bovine milk-derived exosomes as a drug delivery vehicle for miRNA-based therapy

L del Pozo-Acebo, MC López de las Hazas… - International journal of …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene
expression in crucial biological processes, which converts them into high potential …

[HTML][HTML] Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis …

SC Tao, T Yuan, BY Rui, ZZ Zhu, SC Guo… - Theranostics, 2017 - ncbi.nlm.nih.gov
An excess of glucocorticoids (GCs) is reported to be one of the most common causes of
osteonecrosis of the femoral head (ONFH). In addition, GCs can induce bone cell apoptosis …

Exosome as a novel shuttle for delivery of therapeutics across biological barriers

CK Das, BC Jena, I Banerjee, S Das… - Molecular …, 2018 - ACS Publications
The effective delivery of target-specific siRNA to the brain by exploiting the exosomes
derived from dendritic cells renders the paradigm shift for the prospective use of nanosized …

[HTML][HTML] A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

S Rankin-Turner, P Vader, L O'Driscoll, B Giebel… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are complex nanoparticles required for the intercellular transfer
of diverse biological cargoes. Unlike synthetic nanoparticles, EVs may provide a natural …

The transport mechanism of extracellular vesicles at the blood-brain barrier

J Matsumoto, T Stewart, WA Banks… - Current pharmaceutical …, 2017 - ingentaconnect.com
Recently, extracellular vesicles (EVs), like exosomes and microvesicles, have attracted
attention as potent carriers of intercellular communication throughout the body, including the …