Since the proposal of Anfinsen's thermodynamic hypothesis in 1963, our understanding of
protein folding and dynamics has gained significant appreciation of its nuance and …

The structural paradigm that the sequence of a protein encodes for a unique three-
dimensional native fold does not acknowledge the intrinsic plasticity encapsulated in …

While numerous cellular proteins in the HIV envelope are known to alter virus infection,
methodology to rapidly phenotype the virion surface in a high throughput, single virion …

Understanding and reshaping cellular behaviors with synthetic gene networks requires the
ability to sense and respond to changes in the intracellular environment. Intracellular …

Antibodies and cytotoxic T cells represent 2 arms of host defense against pathogens. We
hypothesized that vaccines that induce both high-magnitude CD8+ T cell responses and …

Infectious bronchitis virus (IBV) is a pathogenic coronavirus with high morbidity and mortality
in chicken breeding. Macrophages with normal biofunctions are essential for host immune …

ABSTRACT A subset of HIV-infected individuals termed elite controllers (ECs) maintain
CD4+ T cell counts and control viral replication in the absence of antiretroviral therapy …

The XCL1-XCR1 axis has a potential role in the recruitment of immune cells to the site of
inflammation. The present study aimed to examine the relation of XCL1 serum levels with …

Background P-selectin glycoprotein ligand-1 (PSGL-1/CD162) has been studied extensively
for its role in mediating leukocyte rolling through interactions with its cognate receptor, P …

The complement system represents a crucial part of innate immunity. It contains a diverse
range of soluble activators, membrane-bound receptors, and regulators. Its principal function …