Pathogenesis of allergic diseases and implications for therapeutic interventions

J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

[HTML][HTML] NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches

F Sivandzade, S Prasad, A Bhalerao, L Cucullo - Redox biology, 2019 - Elsevier
Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …

Quercetin prevents LPS-induced oxidative stress and inflammation by modulating NOX2/ROS/NF-kB in lung epithelial cells

OJ Sul, SW Ra - Molecules, 2021 - mdpi.com
Oxidative stress caused by the production of reactive oxygen species (ROS) plays a major
role in inflammatory processes. We hypothesized that modulation of ROS via quercetin may …

Progress in the mechanism and targeted drug therapy for COPD

C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …

The role of macrophages in the development of acute and chronic inflammatory lung diseases

JW Lee, W Chun, HJ Lee, JH Min, SM Kim, JY Seo… - Cells, 2021 - mdpi.com
Macrophages play an important role in the innate and adaptive immune responses of organ
systems, including the lungs, to particles and pathogens. Cumulative results show that …

NF-kappaB signaling in chronic inflammatory airway disease

M Schuliga - Biomolecules, 2015 - mdpi.com
Asthma and chronic obstructive pulmonary disease (COPD) are obstructive airway disorders
which differ in their underlying causes and phenotypes but overlap in patterns of …

Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota

YJ Jang, WK Kim, DH Han, K Lee, G Ko - Gut microbes, 2019 - Taylor & Francis
We evaluated immunometabolic functions of novel Lactobacillus fermentum strains (KBL374
and KBL375) isolated from feces of healthy Koreans. The levels of inflammatory cytokines …

Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets

V Mishra, J Banga, P Silveyra - Pharmacology & Therapeutics, 2018 - Elsevier
Asthma is a complex inflammatory disease characterized by airway inflammation and
hyperresponsiveness. The mechanisms associated with the development and progression …

Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

V Kostenko, O Akimov, O Gutnik, H Kostenko… - Heliyon, 2023 - cell.com
One of the adverse outcomes of acute inflammatory response is progressing to the chronic
stage or transforming into an aggressive process, which can develop rapidly and result in …

Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease

J Hey, M Paulsen, R Toth, D Weichenhan… - Nature …, 2021 - nature.com
Lung diseases, such as cystic fibrosis and COPD, are characterized by mucus obstruction
and chronic airway inflammation, but their mechanistic link remains poorly understood …