cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment

H Zhang, Y Liu, J Liu, J Chen, J Wang, H Hua… - Journal of Hematology & …, 2024 - Springer
Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

The immune regulatory role of adenosine in the tumor microenvironment

J Xing, J Zhang, J Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Adenosine, an immunosuppressive metabolite, is produced by adenosine triphosphate
(ATP) released from dying or stressed cells and is found at high levels in the tumor …

[HTML][HTML] Non-immune cell components in tumor microenvironment influencing lung cancer Immunotherapy

J Zhang, S Liu, X Chen, X Xu, F Xu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Lung cancer (LC) is one of the leading causes of cancer-related deaths worldwide, with a
significant morbidity and mortality rate, endangering human life and health. The introduction …

Energy metabolism as the hub of advanced non-small cell lung cancer management: a comprehensive view in the framework of predictive, preventive, and …

O Bajinka, SY Ouedraogo, O Golubnitschaja, N Li… - EPMA Journal, 2024 - Springer
Energy metabolism is a hub of governing all processes at cellular and organismal levels
such as, on one hand, reparable vs. irreparable cell damage, cell fate (proliferation, survival …

Exploring the pharmacological mechanisms for alleviating OSA: Adenosine A2A receptor downregulation of the PI3K/Akt/HIF‑1 pathway

N Ma, P Liu, N Li, Y Hu, L Kang - Biomedical Reports, 2024 - spandidos-publications.com
Obstructive sleep apnea (OSA) is the most common type of sleep apnea, which leads to
episodes of intermittent hypoxia due to obstruction of the upper airway. A key feature of OSA …

Integrating network pharmacology with molecular docking for elucidation of molecular biological mechanisms of Jiedu Qingjin formula for non-small cell lung cancer

B Xu, W Dan, J Wu, X Wang, X Qin, Y Han… - Journal of …, 2023 - Taylor & Francis
Traditional Chinese medicine is an important part of complementary alternative medicine.
Jiedu Qingjin formula (JDQJF) is an effective national invention patent for the treatment of …

[图书][B] Art of tumor immunity: extricating hypoxia-driven immunosuppression in the solid tumor microenvironment

ATH Min - 2023 - search.proquest.com
The fate of tumors, from initiation to in situ carcinoma and ultimately metastasis, is intricately
tied to the balance between the immune system's effector cytotoxic and tolerogenic …