Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …

MG Savelieff, G Nam, J Kang, HJ Lee, M Lee… - Chemical …, 2018 - ACS Publications
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Mitochondria as potential targets in Alzheimer disease therapy: an update

G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Phospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets

J Kopecka, P Trouillas, AČ Gašparović, E Gazzano… - Drug resistance …, 2020 - Elsevier
Lipids, phospholipids and cholesterol in particular, are the predominant components of the
plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …

Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction: potential diagnostic biomarkers and therapeutic targets

MG Scioli, G Storti, F D'Amico… - Journal of Clinical …, 2020 - mdpi.com
Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

[HTML][HTML] Retinopathy of prematurity: A review of pathophysiology and signaling pathways

M Fevereiro-Martins, C Marques-Neves… - survey of …, 2023 - Elsevier
Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

[HTML][HTML] Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer

L Andrisic, D Dudzik, C Barbas, L Milkovic, T Grune… - Redox biology, 2018 - Elsevier
Association of oxidative stress with carcinogenesis is well known, but not understood well,
as is pathophysiology of oxidative stress generated during different types of anti-cancer …

Mechanisms of oxidative stress and therapeutic targets following intracerebral hemorrhage

Z Yao, Q Bai, G Wang - Oxidative Medicine and Cellular …, 2021 - Wiley Online Library
Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS)
following intracerebral hemorrhage (ICH) and plays an important role in secondary brain …

Disorders of endogenous and exogenous antioxidants in neurological diseases

I Korczowska-Łącka, B Słowikowski, T Piekut, M Hurła… - Antioxidants, 2023 - mdpi.com
In diseases of the central nervous system, such as Alzheimer's disease (AD), Parkinson's
disease (PD), stroke, amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and …

The novel role of mitochondrial citrate synthase and citrate in the pathophysiology of Alzheimer's disease

N Chhimpa, N Singh, N Puri… - Journal of Alzheimer's …, 2023 - content.iospress.com
Citrate synthase is a key mitochondrial enzyme that utilizes acetyl-CoA and oxaloacetate to
form citrate in the mitochondrial membrane, which participates in energy production in the …

The effects of probiotics on inflammation, endothelial dysfunction, and atherosclerosis progression: a mechanistic overview

M Mahdavi-Roshan, A Salari, J Kheirkhah… - Heart, Lung and …, 2022 - Elsevier
Introduction The relationship between the intestinal microbiota dysbiosis, inflammation, and
cardiovascular disorders (CVDs) has become evident, based on a growing body of literature …