For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two
principal mechanisms are responsible for this dysfunction; mutation and downregulation of …

The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are
extensively focused areas of research in the context of cancer. Both the catabolic pathways …

The therapeutic armamentarium of acute myeloid leukemia (AML) has rapidly expanded in
the past few years, driven largely by translational research into its genomic landscape and …

The two murine double minute (MDM) family members MDM2 and MDMX are at the center
of an intense clinical assessment as molecular target for the management of cancer. Indeed …

Opinion statement Approximately 40–45% of younger and 10–20% of older adults with
acute myeloid leukemia (AML) will be cured with current standard chemotherapy. The …

The tumor suppressor p53 is often inactivated via its interaction with endogenous inhibitors
mouse double minute 4 homolog (MDM4 or MDMX) or mouse double minute 2 homolog …

Abstract p53 is the major tumor suppressor and the most frequently inactivated gene in
cancer. p53 could be disabled either by mutations or by upstream negative regulators …

BACKGROUND: Cardiomyopathy is characterized by the pathological accumulation of
resident cardiac fibroblasts that deposit ECM (extracellular matrix) and generate a fibrotic …