A wide array of microorganisms, including many novel, phylogenetically deeply rooted taxa,
survive and thrive in extreme environments. These unique and reduced-complexity …

Despite the surge of microbial genome data, experimental testing is important to confirm
inferences about the cell biology, ecological roles and evolution of microorganisms. As the …

The accrual of genomic data from both cultured and uncultured microorganisms provides
new opportunities to develop systematic taxonomies based on evolutionary relationships …

In the ongoing debates about eukaryogenesis—the series of evolutionary events leading to
the emergence of the eukaryotic cell from prokaryotic ancestors—members of the Asgard …

The number and diversity of known CRISPR–Cas systems have substantially increased in
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas …

Abstract The Transporter Classification Database (TCDB; tcdb. org) is a freely accessible
reference resource, which provides functional, structural, mechanistic, medical and …

The origin of eukaryotes remains unclear,,–. Current data suggest that eukaryotes may have
emerged from an archaeal lineage known as 'Asgard'archaea,. Despite the eukaryote-like …

Asgard is a recently discovered superphylum of archaea that appears to include the closest
archaeal relatives of eukaryotes,,,–. Debate continues as to whether the archaeal ancestor …

Compared to bacteria, our knowledge of archaeal biology is limited. Historically,
microbiologists have mostly relied on culturing and single-gene diversity surveys to …

Abstract The MEROPS database (http://www. ebi. ac. uk/merops/) is an integrated source of
information about peptidases, their substrates and inhibitors. The hierarchical classification …