Mitochondria are double membrane organelles in eukaryotic cells that provide energy by
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …

Cell death and injury often lead to release or exposure of intracellular molecules called
damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These …

Mitochondria contain their own genetic system and undergo a unique mode of cytoplasmic
inheritance. Each organelle has multiple copies of a covalently closed circular DNA genome …

Mitochondrial disorders are a group of clinically heterogeneous diseases, commonly
defined by a lack of cellular energy due to oxidative phosphorylation (OXPHOS) defects …

Cytoplasmic RNA granules play a central role in mRNA metabolism, but the importance of
mitochondrial RNA granules remains relatively unexplored. We characterized their …

Mitochondrial transcription factor A (mtTFA, mtTF1, TFAM) is an essential protein that binds
mitochondrial DNA (mtDNA) with and without sequence specificity to regulate both …

Mitochondrial dysfunction is heavily implicated in the multifactorial aging process. Aging
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …

Regulation of mitochondrial biogenesis is essential for proper cellular functioning.
Mitochondrial DNA (mtDNA) depletion and the resulting mitochondrial malfunction have …

The mitochondrion was originally a free-living prokaryotic organism, which explains the
presence of a compact mammalian mitochondrial DNA (mtDNA) in contempory mammalian …

Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …