Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes
SUMMARY TDP-43 nuclear clearance and cytoplasmic aggregation are hallmarks of TDP-
43 proteinopathies. We recently demonstrated that binding to endogenous nuclear GU-rich …
43 proteinopathies. We recently demonstrated that binding to endogenous nuclear GU-rich …
A hydrophobic core stabilizes the residual structure in the RRM2 intermediate state of the ALS-linked protein TDP-43
BC Mackness, BR Morgan, LM Deveau, SV Kathuria… - bioRxiv, 2024 - biorxiv.org
Folding intermediates mediate both protein folding and the misfolding and aggregation
observed in human diseases, including amyotrophic lateral sclerosis (ALS), and are prime …
observed in human diseases, including amyotrophic lateral sclerosis (ALS), and are prime …