Dissecting the genetics of complex traits using summary association statistics
B Pasaniuc, AL Price - Nature reviews genetics, 2017 - nature.com
During the past decade, genome-wide association studies (GWAS) have been used to
successfully identify tens of thousands of genetic variants associated with complex traits and …
successfully identify tens of thousands of genetic variants associated with complex traits and …
Colocalization of GWAS and eQTL signals detects target genes
The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding
regions of the genome. One possible hypothesis is that these GWAS risk loci alter the …
regions of the genome. One possible hypothesis is that these GWAS risk loci alter the …
Insights into type 1 diabetes provided by genetic analyses
G Morahan - Current Opinion in Endocrinology, Diabetes and …, 2012 - journals.lww.com
Insights into type 1 diabetes provided by genetic analyses : Current Opinion in Endocrinology,
Diabetes and Obesity Insights into type 1 diabetes provided by genetic analyses : Current …
Diabetes and Obesity Insights into type 1 diabetes provided by genetic analyses : Current …
Widespread allelic heterogeneity in complex traits
F Hormozdiari, A Zhu, G Kichaev, CJT Ju… - The American Journal of …, 2017 - cell.com
Recent successes in genome-wide association studies (GWASs) make it possible to
address important questions about the genetic architecture of complex traits, such as allele …
address important questions about the genetic architecture of complex traits, such as allele …
Multiple testing correction in linear mixed models
Background Multiple hypothesis testing is a major issue in genome-wide association studies
(GWAS), which often analyze millions of markers. The permutation test is considered to be …
(GWAS), which often analyze millions of markers. The permutation test is considered to be …
Identification, deployment, and transferability of quantitative trait loci from genome-wide association studies in plants
Over the past decade, the use of genome-wide association studies (GWAS) in plant
breeding for discovery and validation of quantitative trait loci (QTL) has vastly increased …
breeding for discovery and validation of quantitative trait loci (QTL) has vastly increased …
DISSCO: direct imputation of summary statistics allowing covariates
Background: Imputation of individual level genotypes at untyped markers using an external
reference panel of genotyped or sequenced individuals has become standard practice in …
reference panel of genotyped or sequenced individuals has become standard practice in …
[HTML][HTML] Regional replication of association with refractive error on 15q14 and 15q25 in the Age-Related Eye Disease Study cohort
Purpose Refractive error is a complex trait with multiple genetic and environmental risk
factors, and is the most common cause of preventable blindness worldwide. The common …
factors, and is the most common cause of preventable blindness worldwide. The common …
Estimating colocalization probability from limited summary statistics
Background Colocalization is a statistical method used in genetics to determine whether the
same variant is causal for multiple phenotypes, for example, complex traits and gene …
same variant is causal for multiple phenotypes, for example, complex traits and gene …
Enhanced methods to detect haplotypic effects on gene expression
Motivation Expression quantitative trait loci (eQTLs), genetic variants associated with gene
expression levels, are identified in eQTL mapping studies. Such studies typically test for an …
expression levels, are identified in eQTL mapping studies. Such studies typically test for an …