Models of traumatic brain injury-highlights and drawbacks

Q Zhao, J Zhang, H Li, H Li, F Xie - Frontiers in neurology, 2023 - frontiersin.org
Traumatic brain injury (TBI) is the leading cause for high morbidity and mortality rates in
young adults, survivors may suffer from long-term physical, cognitive, and/or psychological …

[HTML][HTML] White matter damage and degeneration in traumatic brain injury

RC Armstrong, GM Sullivan, DP Perl, JD Rosarda… - Trends in …, 2024 - cell.com
Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …

Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier

H Song, PP McEwan, KE Ameen-Ali, A Tomasevich… - Acta …, 2022 - Springer
Despite being a major health concern, little is known about the pathophysiological changes
that underly concussion. Nonetheless, emerging evidence suggests that selective damage …

Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects

F Kobeissy, M Goli, H Yadikar, Z Shakkour… - Frontiers in …, 2023 - frontiersin.org
Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has
garnered significant attention in the context of neurotrauma research. Neuroproteomics …

How neurons maintain their axons long-term: an integrated view of axon biology and pathology

G Smith, ST Sweeney, CJ O'Kane… - Frontiers in Neuroscience, 2023 - frontiersin.org
Axons are processes of neurons, up to a metre long, that form the essential biological cables
wiring nervous systems. They must survive, often far away from their cell bodies and up to a …

Neuronal tau pathology worsens late-phase white matter degeneration after traumatic brain injury in transgenic mice

F Yu, D Iacono, DP Perl, C Lai, J Gill, TQ Le, P Lee… - Acta …, 2023 - Springer
Traumatic brain injury (TBI) causes diffuse axonal injury which can produce chronic white
matter pathology and subsequent post-traumatic neurodegeneration with poor patient …

Contralesional anodal transcranial direct current stimulation promotes intact corticospinal tract axonal sprouting and functional recovery after traumatic brain injury in …

B Chen, Q Tan, H Zhang, W Chu… - … and Neural Repair, 2024 - journals.sagepub.com
Background Anodal transcranial direct current stimulation (AtDCS), a neuromodulatory
technique, has been applied to treat traumatic brain injury (TBI) in patients and was reported …

Sex differences in the extent of acute axonal pathologies after experimental concussion

H Song, A Tomasevich, A Paolini, KD Browne… - Acta …, 2024 - Springer
Although human females appear be at a higher risk of concussion and suffer worse
outcomes than males, underlying mechanisms remain unclear. With increasing recognition …

Viscoelastic cues to induce stem cell migration and neuronal differentiation in cell-free hydrogel-assisted TBI recovery

X Liu, C Wu, Y Zhang, G Li, S Chen, Z Chen… - Chemical Engineering …, 2024 - Elsevier
The concept of tissue-inducing biomaterials, such as osteoinductive biomaterials, has
inspired the design of regenerative material with biomimetic cues to manipulate cell/tissue …

Targeting of nanoparticles to the cerebral vasculature after traumatic brain injury

S Omo-Lamai, J Nong, K Savalia, BJ Kelley, J Wu… - Plos one, 2024 - journals.plos.org
Traumatic brain injury has faced numerous challenges in drug development, primarily due to
the difficulty of effectively delivering drugs to the brain. However, there is a potential solution …