The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma
and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Arachidonic acid is released from membrane phospholipids upon cell stimulation (for
example, by immune complexes and calcium ionophores) and converted to leukotrienes by …

Prostaglandins, leukotrienes, platelet-activating factor, lysophosphatidic acid, sphingosine 1-
phosphate, and endocannabinoids, collectively referred to as lipid mediators, play pivotal …

Objective: To review the biochemistry and biological activities of leukotrienes, focusing on
their role in the mediation of inflammatory diseases. Data Sources: MEDLINE (1966-1994) …

Mammalian lipoxygenases: molecular structures and functions - ScienceDirect Skip to main
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Since a review on this topic in this Journal appeared (Wolfe, 1982), the CNS has proved to
be a major focus in eicosanoid research. Although our knowledge is limited at the moment …

SEVERAL inflammatory diseases, including asthma, arthritis and psoriasis are associated
with the production of leukotrienes by neutrophils, mast cells and macrophages1–3. The …