Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS

C Wyart, M Carbo-Tano, Y Cantaut-Belarif… - Nature Reviews …, 2023 - nature.com
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and
whose composition changes as a function of an animal's physiological state. Ciliated …

Taste transduction and channel synapses in taste buds

A Taruno, K Nomura, T Kusakizako, Z Ma… - … -European Journal of …, 2021 - Springer
The variety of taste sensations, including sweet, umami, bitter, sour, and salty, arises from
diverse taste cells, each of which expresses specific taste sensor molecules and associated …

An evolutionarily conserved gene family encodes proton-selective ion channels

YH Tu, AJ Cooper, B Teng, RB Chang, DJ Artiga… - Science, 2018 - science.org
Ion channels form the basis for cellular electrical signaling. Despite the scores of genetically
identified ion channels selective for other monatomic ions, only one type of proton-selective …

Cellular and neural responses to sour stimuli require the proton channel Otop1

B Teng, CE Wilson, YH Tu, NR Joshi, SC Kinnamon… - Current Biology, 2019 - cell.com
The sense of taste allows animals to sample chemicals in the environment prior to ingestion.
Of the five basic tastes, sour, the taste of acids, had remained among the most mysterious …

The proton channel OTOP1 is a sensor for the taste of ammonium chloride

Z Liang, CE Wilson, B Teng, SC Kinnamon… - Nature …, 2023 - nature.com
Abstract Ammonium (NH4+), a breakdown product of amino acids that can be toxic at high
levels, is detected by taste systems of organisms ranging from C. elegans to humans and …

[图书][B] Anatomy & physiology for speech, language, and hearing

JA Seikel, DG Drumright, DJ Hudock - 2023 - books.google.com
With many exciting enhancements and robust online resources, the seventh edition of
Anatomy & Physiology for Speech, Language, and Hearing provides a solid foundation in …

Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

JR Sternberg, AE Prendergast, L Brosse… - Nature …, 2018 - nature.com
Defects in cerebrospinal fluid (CSF) flow may contribute to idiopathic scoliosis. However, the
mechanisms underlying detection of CSF flow in the central canal of the spinal cord are …

Progress and renewal in gustation: new insights into taste bud development

LA Barlow - Development, 2015 - journals.biologists.com
The sense of taste, or gustation, is mediated by taste buds, which are housed in specialized
taste papillae found in a stereotyped pattern on the surface of the tongue. Each bud …

CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

UL Böhm, A Prendergast, L Djenoune… - Nature …, 2016 - nature.com
Throughout vertebrates, cerebrospinal fluid-contacting neurons (CSF-cNs) are ciliated cells
surrounding the central canal in the ventral spinal cord. Their contribution to modulate …

Clinical role of extraoral bitter taste receptors

J Jeruzal-Świątecka, W Fendler… - International Journal of …, 2020 - mdpi.com
Humans can recognise five basic tastes: sweet, sour, salty, bitter and umami. Sour and salty
substances are linked to ion channels, while sweet, bitter and umami flavours are …