Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

Chemotherapy is currently the main treatment for unresectable or advanced postoperative
gastric cancers. However, its efficacy is negatively affected by the occurrence of …

Malignant cells utilize diverse strategies that enable them to thrive under adverse conditions
while simultaneously inhibiting the development of anti-tumor immune responses. Hostile …

The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …

Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …

Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …

Melanoma is the deadliest form of skin cancer and its incidence is rising, creating a costly
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …

Perturbation of endoplasmic reticulum (ER) homeostasis results in a stress condition termed
“ER stress” determining the activation of a finely regulated program defined as unfolded …

Kaempferol, a flavonoid, found in traditional medicine, fruits, and vegetables, and an HDAC
inhibitor, is a powerful anti-cancer reagent against various cancer cell lines. However …