The complement system in age-related macular degeneration
Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …
disease of the retina, which culminates in blindness and affects mainly the elderly …
Inflammation and its role in age-related macular degeneration
A Kauppinen, JJ Paterno, J Blasiak, A Salminen… - Cellular and molecular …, 2016 - Springer
Inflammation is a cellular response to factors that challenge the homeostasis of cells and
tissues. Cell-associated and soluble pattern-recognition receptors, eg Toll-like receptors …
tissues. Cell-associated and soluble pattern-recognition receptors, eg Toll-like receptors …
IL-1 family members mediate cell death, inflammation and angiogenesis in retinal degenerative diseases
Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …
diseases. The recruitment and activation of both resident microglia and recruited …
Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration
Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …
Complement factor H in AMD: Bridging genetic associations and pathobiology
CB Toomey, LV Johnson, CB Rickman - Progress in retinal and eye …, 2018 - Elsevier
Abstract Age-Related Macular Degeneration (AMD) is a complex multifactorial disease
characterized in its early stages by lipoprotein accumulations in Bruch's Membrane (BrM) …
characterized in its early stages by lipoprotein accumulations in Bruch's Membrane (BrM) …
Bruch's membrane: a key consideration with complement-based therapies for age-related macular degeneration
The complement system is crucial for immune surveillance, providing the body's first line of
defence against pathogens. However, an imbalance in its regulators can lead to …
defence against pathogens. However, an imbalance in its regulators can lead to …
Drusen in patient-derived hiPSC-RPE models of macular dystrophies
Age-related macular degeneration (AMD) and related macular dystrophies (MDs) are a
major cause of vision loss. However, the mechanisms underlying their progression remain ill …
major cause of vision loss. However, the mechanisms underlying their progression remain ill …
Retinal pigment epithelium in the pathogenesis of age‐related macular degeneration and photobiomodulation as a potential therapy?
The retinal pigment epithelium (RPE) comprises a monolayer of cells located between the
neuroretina and the choriocapillaries. The RPE serves several important functions in the …
neuroretina and the choriocapillaries. The RPE serves several important functions in the …
Targeting complement components C3 and C5 for the retina: key concepts and lingering questions
Age-related macular degeneration (AMD) remains a major cause of legal blindness, and
treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation …
treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation …
[HTML][HTML] Subretinal pigment epithelial deposition of drusen components including hydroxyapatite in a primary cell culture model
Purpose: Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals
that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's …
that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's …