Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …

Phagocytosis is a dynamic process that requires an intricate interplay between phagocytic
receptors, membrane lipids, and numerous signalling proteins and their effectors, to …

Background Abnormal macrophage function caused by dysfunctional cystic fibrosis
transmembrane conductance regulator (CFTR) is a critical contributor to chronic airway …

Phagosomes must maintain membrane integrity to exert their microbicidal function. Some
microorganisms, however, survive and grow within phagosomes. In such instances …

The decision whether endosomes enter the degradative or recycling pathway in mammalian
cells is of fundamental importance for pathogen killing, and its malfunctioning has …

Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …

Pathogens must adapt to disparate environments in permissive host species, a feat that is
especially pronounced for vector-borne microbes, which transition between vertebrate hosts …

Cystic fibrosis (CF) is caused by mutations of the cystic fibrosis transmembrane conductance
regulator (CFTR) gene. Chronic inflammation and decline in lung function are major reasons …

Endosomes are essential cellular stations where endocytic and secretory trafficking routes
converge. Proteins transiting at endosomes can be degraded via lysosome, or recycled to …

Burkholderia cenocepacia is a member of the Burkholderia cepacia complex (Bcc), a group
of bacteria with members responsible for causing lung infections in cystic fibrosis (CF) …