Highlights•Complex glycans play multifaceted roles in interplay between virus and its
host.•Host glycans serve co-receptors or specific primary receptors for viral entry.•Viral …

Highlights•Viral protein simulations are among the largest all-atom simulations ever
published.•All-atom simulations reveal the dynamics of viral proteins at chemical …

The N1 neuraminidases (NAs) of avian and pandemic human influenza viruses contain
tyrosine and asparagine, respectively, at position 347 on the rim of the catalytic site; the …

Influenza remains a serious health threat, with resistance to frontline drugs becoming more
common, and new treatments urgently sought. One strategy for the inhibition of the …

Adaptation of influenza A viruses to new hosts are rare events but are the basis for
emergence of new influenza pandemics in the human population. Thus, understanding the …

Background Hemagglutinin (HA) of influenza A is one of the key virulence factors that
mediates the release of viral components in host cells. HA is initially synthesized as a …

The emergence of escape-mutants of influenza hemagglutinin (HA) following vaccination
compels the yearly re-formulation of flu vaccines. Since binding the sialic acid receptor …

Influenza A viruses are rapidly evolving pathogens with the potential for novel strains to
emerge and result in pandemic outbreaks in humans. Some avian-adapted subtypes have …

The development of small-molecule inhibitors of influenza virus Hemagglutinin could be
relevant to the opposition of the diffusion of new pandemic viruses. In this work, we made …

Avian influenza A viruses, which can also propagate between humans, present serious
pandemic threats, particularly in Asia. The specificity (selectivity) of interactions between the …