Axonal endoplasmic reticulum dynamics and its roles in neurodegeneration
The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …
Endoplasmic reticulum–plasma membrane contact sites: Regulators, mechanisms, and physiological functions
The endoplasmic reticulum (ER) forms direct membrane contact sites with the plasma
membrane (PM) in eukaryotic cells. These ER-PM contact sites play essential roles in lipid …
membrane (PM) in eukaryotic cells. These ER-PM contact sites play essential roles in lipid …
Roles for the endoplasmic reticulum in regulation of neuronal calcium homeostasis
NE Karagas, K Venkatachalam - Cells, 2019 - mdpi.com
By influencing Ca2+ homeostasis in spatially and architecturally distinct neuronal
compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function …
compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function …
The endoplasmic reticulum and its contacts: Emerging roles in axon development, neurotransmission, and degeneration
M Kuijpers, PT Nguyen, V Haucke - The Neuroscientist, 2024 - journals.sagepub.com
The neuronal endoplasmic reticulum (ER) consists of a dynamic, tubular network that
extends all the way from the soma into dendrites, axons, and synapses. This morphology …
extends all the way from the soma into dendrites, axons, and synapses. This morphology …
Homeostatic scaling of active zone scaffolds maintains global synaptic strength
Synaptic terminals grow and retract throughout life, yet synaptic strength is maintained within
stable physiological ranges. To study this process, we investigated Drosophila endophilin …
stable physiological ranges. To study this process, we investigated Drosophila endophilin …
NeurodegenERation: the central role for ER contacts in neuronal function and axonopathy, lessons from hereditary spastic paraplegias and related diseases
PC Fowler, ME Garcia-Pardo, JC Simpson… - Frontiers in …, 2019 - frontiersin.org
The hereditary spastic paraplegias (HSPs) are a group of inherited neurodegenerative
conditions whose characteristic feature is degeneration of the longest axons within the …
conditions whose characteristic feature is degeneration of the longest axons within the …
Functions of vertebrate ferlins
AV Bulankina, S Thoms - Cells, 2020 - mdpi.com
Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics
within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six …
within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six …
The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens)
The Betta fish displays a remarkable variety of phenotypes selected during domestication.
However, the genetic basis underlying these traits remains largely unexplored. Here, we …
However, the genetic basis underlying these traits remains largely unexplored. Here, we …
[HTML][HTML] Excess glutamate release triggers subunit-specific homeostatic receptor scaling
Ionotropic glutamate receptors (GluRs) are targets for modulation in Hebbian and
homeostatic synaptic plasticity and are remodeled by development, experience, and …
homeostatic synaptic plasticity and are remodeled by development, experience, and …
The axonal endoplasmic reticulum: one organelle—many functions in development, maintenance, and plasticity
The endoplasmic reticulum (ER) is highly conserved in eukaryotes and neurons. Indeed, the
localization of the organelle in axons has been known for nearly half a century. However, the …
localization of the organelle in axons has been known for nearly half a century. However, the …