Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …

An increased incidence of narcolepsy was seen in many countries after the pandemic H1N1
influenza vaccination campaign in 2009–2010. The H1N1 vaccine–narcolepsy connection is …

This article addresses the clinical presentation, diagnosis, pathophysiology and
management of narcolepsy type 1 and 2, with a focus on recent findings. A low level of …

The orexins, also known as hypocretins, are two neuropeptides (orexin A and B or
hypocretin 1 and 2) produced by a few thousand neurons located in the lateral …

Abstract Study Objectives To assess the test–retest reliability of the polysomnography–
multiple sleep latency test (PSG–MSLT) diagnostic classification and measures and to study …

The classification of the central disorders of hypersomnolence has undergone multiple
iterations in an attempt to capture biologically meaningful disease entities in the absence of …

Histamine was first identified in the brain about 50 years ago, but only in the last few years
have researchers gained an understanding of how it regulates sleep/wake behavior. We …

Narcolepsy type 1 (NT1) is a chronic orphan disorder, caused by the selective and
irreversible loss of hypocretin/orexin (ORX) neurons, by a probable autoimmune process …

Narcolepsy type 1 is a life-long, severe, multifaceted disease often arising in childhood or
adolescence. Beyond the classical symptoms (excessive daytime sleepiness, cataplexy …