Blood-based biomarker in Parkinson's disease: potential for future applications in clinical research and practice

L Tönges, C Buhmann, S Klebe, J Klucken… - Journal of Neural …, 2022 - Springer
The clinical presentation of Parkinson's disease (PD) is both complex and heterogeneous,
and its precise classification often requires an intensive work-up. The differential diagnosis …

Blood and cerebrospinal fluid biomarkers of inflammation in Parkinson's disease

M Zimmermann, K Brockmann - Journal of Parkinson's …, 2022 - content.iospress.com
Given the clear role of inflammation in the pathogenesis of Parkinson's disease (PD) and its
impact on incidence and phenotypical characteristics, this review provides an overview with …

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease

Z Fan, YT Pan, ZY Zhang, H Yang, SY Yu… - Journal of …, 2020 - Springer
Background Emerging evidence indicates that inflammasome-induced inflammation plays a
crucial role in the pathogenesis of Parkinson's disease (PD). Several proteins including α …

Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of …

MN Karpenko, AA Vasilishina, EA Gromova… - Cellular …, 2018 - Elsevier
Several parameters representing the clinical diversity of Parkinson's disease (PD), including
severity, phenotypes, cognitive decline, anxiety and depression were analyzed to examine …

Peripheral inflammatory markers TNF-α and CCL2 revisited: association with Parkinson's disease severity

G Xiromerisiou, C Marogianni… - International journal of …, 2022 - mdpi.com
One of the major mediators of neuroinflammation in PD is tumour necrosis factor alpha (TNF-
α), which, similar to other cytokines, is produced by activated microglia and astrocytes …

[PDF][PDF] The effects of probiotic supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinson's disease: a randomized …

S Borzabadi, S Oryan, A Eidi, Z Asemi - Archives of Iranian medicine, 2018 - journalaim.com
Background: This study was conducted to evaluate the effects of probiotic supplementation
on gene expression related to inflammation, insulin and lipid in patients with Parkinson's …

How should we be using biomarkers in trials of disease modification in Parkinson's disease?

N Vijiaratnam, T Foltynie - Brain, 2023 - academic.oup.com
The recent validation of the α-synuclein seed amplification assay as a biomarker with high
sensitivity and specificity for the diagnosis of Parkinson's disease has formed the backbone …

Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson's …

LN Eidson, GT Kannarkat, CJ Barnum, J Chang… - Journal of …, 2017 - Springer
Background Efforts to identify fluid biomarkers of Parkinson's disease (PD) have intensified
in the last decade. As the role of inflammation in PD pathophysiology becomes increasingly …

Parkinson's disease peripheral immune biomarker profile: a multicentre, cross-sectional and longitudinal study

Y Li, Y Yang, A Zhao, N Luo, M Niu, W Kang… - Journal of …, 2022 - Springer
Background Inflammations play crucial role in the pathogenesis of Parkinson's disease (PD),
however, their possible value in the diagnosis or tracking of the progress of PD is still limited …

Serum inflammatory cytokines levels and the correlation analyses in Parkinson's disease

J Fu, S Chen, J Liu, J Yang, R Ou, L Zhang… - Frontiers in Cell and …, 2023 - frontiersin.org
Objective: To investigate the serum levels of inflammatory cytokines and the correlations
with Parkinson's disease (PD) clinical symptoms. Methods: Serum levels of the cytokines …