The α-pyrone moiety is a structural feature found in a huge variety of biologically active
metabolites. In recent times new insights into additional biosynthetic mechanisms, yielding …

Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic
fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA …

Gregatin A (1) is a fungal polyketide featuring an alkylated furanone core, but the
biosynthetic mechanism to furnish the intriguing molecular skeleton has yet to be elucidated …

Type III polyketide synthases (PKSs) produce secondary metabolites with diverse biological
activities, including antimicrobials. While they have been extensively studied in plants and …

Myxopyronins are α-pyrone antibiotics produced by the terrestrial bacterium Myxococcus
fulvus Mx f50 and possess antibacterial activity against Gram-positive and Gram-negative …

Microorganisms produce a vast array of biologically active metabolites. Such compounds
are applied by humans to positively influence their health and, therefore, natural products …

Many microbial secondary metabolites are produced by multienzyme complexes comprising
nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). The …

In contrast to stilbene biosynthesis by type III polyketide synthase in plants, in bacteria
stilbene is produced by the collaboration of two enzymes in Photorhabdus luminescens: the …

2-quinolones are privileged scaffolds for drug discovery that are relatively rare in nature.
Here, we characterise two promiscuous fungal polyketide synthases AthePKS and FerePKS …

Originally annotated as the initiator of fatty acid synthesis (FAS), β‐ketoacyl‐acyl carrier
protein synthase III (KAS III) is a unique component of the bacterial FAS system. Novel …