Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …

In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

The liver X receptors (LXRs) are nuclear receptors that play central roles in the
transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that …

Late-onset sporadic Alzheimer's disease is a heterogeneous disorder. In elderly patients,
increasing evidence suggests a link between this neurodegenerative disease, and vascular …

The liver X receptors α and β (LXRα and LXRβ) are members of the nuclear receptor family
of proteins that are critical for the control of lipid homeostasis in vertebrates. The …

First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified
as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR …

The vertebrate lung consists of multiple cell types that are derived primarily from endodermal
and mesodermal compartments of the early embryo. The process of pulmonary …

Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor
superfamily. There are two LXR isoforms termed α and ß which upon activation form …

Failure of remyelination underlies the progressive nature of demyelinating diseases such as
multiple sclerosis. Macrophages and microglia are crucially involved in the formation and …