Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …

Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals'
targeted and effective administration. However, the intricate interplay between drug …

The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …

Recent research in drug discovery dealing with many faces difficulties, including
development of new drugs during disease outbreak and drug resistance due to rapidly …

Since ancient times, natural medicines have had paramount importance in bolstering
biotherapeutics to treat various diseases. The World Health Organization (WHO) revealed …

A pervasive challenge in drug design is determining how to expand a ligand─ a small
molecule that binds to a target biomolecule─ in order to improve various properties of the …

The accumulation of massive data in the plethora of Cheminformatics databases has made
the role of big data and artificial intelligence (AI) indispensable in drug design. This has …

Drug discovery is the most expensive, time-demanding, and challenging project in
biopharmaceutical companies which aims at the identification and optimization of lead …

Development of fluorescence polarization (FP) assays, especially in a competitive manner,
is a potent and mature tool for measuring the binding affinities of small molecules. This …

With the aging of the population, treatment of conditions emerging in old age, such as
neurodegenerative disorders, has become a major medical challenge. Of these, Alzheimer's …