Depression is a polygenic and highly complex psychiatric disorder that remains a major
burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) …

Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate …

Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …

The personality trait of neuroticism refers to relatively stable tendencies to respond with
negative emotions to threat, frustration, or loss. Individuals in the population vary markedly …

Background: Recent studies demonstrate that the rapid antidepressant ketamine increases
spine number and function in the medial prefrontal cortex (mPFC), and that these effects are …

The brain is a major metabolizer of oxygen and yet has relatively feeble protective
antioxidant mechanisms. This paper reviews the Janus‐faced properties of reactive oxygen …

The neurotrophins are a family of proteins that are essential for the development of the
vertebrate nervous system. Each neurotrophin can signal through two different types of cell …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

BACKGROUND: Converging lines of evidence implicate the neurotrophin brain-derived
neurotrophic factor (BDNF) in the pathophysiology of major depression. Recent studies have …

Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) is
associated with the pathophysiology of major depressive disorder (MDD). In this mini review …