Various self-cleaving ribozymes appearing in nature catalyze the sequence-specific
intramolecular cleavage of RNA and can be engineered to catalyze cleavage of appropriate …

Despite the big data era, observational data continue to be a limiting factor in the
environmental sciences. To collect the most informative field data, studies on the value of …

Trillions of microorganisms, collectively known as the microbiome, inhabit our bodies with
the gut microbiome being of particular interest in biomedical research. Bacteriophages, the …

Eukaryotes possess eight highly conserved Lsm (like Sm) proteins that assemble into
circular, heteroheptameric complexes, bind RNA, and direct a diverse range of biological …

Summary Gene-by-environment (GxE) interactions, in which a genetic variant's phenotypic
effect is condition specific, are fundamental for understanding fitness landscapes and …

Despite their importance in a wide range of living organisms, self-cleaving ribozymes in the
human genome are few and poorly studied. Here, we performed deep mutational scanning …

RNA enzymes serve as a potentially powerful platform from which to design catalysts and
engineer new biotechnology. A fundamental understanding of these systems provides …

Cotranscriptionally encoded RNA strand displacement (ctRSD) circuits are an emerging tool
for programmable molecular computation, with potential applications spanning in vitro …

The spliceosome removes introns from precursor messenger RNA (pre-mRNA) to produce
mature mRNA. Prior to catalysis, spliceosomes are assembled de novo onto pre-mRNA …

CPEB3 ribozyme is a self-cleaving RNA that occurs naturally in mammals and requires
divalent metal ions for efficient activity. Ribozymes exhibit preferences for specific metal …