Metabolic derangement by Arsenic: a review of the mechanisms

K Bibha, TM Akhigbe, MA Hamed… - Biological Trace Element …, 2024 - Springer
Studies have implicated arsenic exposure in various pathological conditions, including
metabolic disorders, which have become a global phenomenon, affecting developed …

Cardiometabolic disorder and erectile dysfunction

D Adeyemi, D Arokoyo, M Hamed, A Dare… - Cell Biochemistry and …, 2024 - Springer
Erectile dysfunction (ED), which is defined as the inability to attain and maintain a
satisfactory penile erection to sufficiently permit sexual intercourse, is a consequence and …

Acetate Abates Arsenic-Induced Male Reproductive Toxicity by Suppressing HDAC and Uric Acid–Driven Oxido-inflammatory NFkB/iNOS/NO Response in Rats

EE Besong, TM Akhigbe, JN Obimma… - … Trace Element Research, 2024 - Springer
Arsenic is associated with male reproductive toxicity through histone deacetylation and
oxido-inflammatory injury. Notwithstanding, short-chain fatty acids such as acetate exert anti …

Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats

AU Rahman, F Alam, M Khan, M Sarfraz, A Basit… - Molecules, 2023 - mdpi.com
The traditional use of Mirabilis jalapa L. roots to enhance male sexual performance
prompted us to assess the in silico, in vitro, and in vivo aphrodisiac activities of its …

Impact of arsenic on male and female reproductive function: a review of the pathophysiology and potential therapeutic strategies

AE Adeogun, OD Ogunleye, TM Akhigbe… - Naunyn-Schmiedeberg's …, 2024 - Springer
Arsenic is a ubiquitous metalloid and heavy metal that contributes to the global decline in
human fertility. Humans are constantly exposed to arsenic through biotic and abiotic …

Sodium acetate abates lead-induced sexual dysfunction by upregulating testosterone-dependent eNOS/NO/cGMP signaling and activating Nrf2/HO-1 in male Wistar …

EE Besong, PJ Ashonibare, TM Akhigbe… - Naunyn-Schmiedeberg's …, 2024 - Springer
Oxidative stress has been linked with lead toxicity, including lead-induced sexual
dysfunction. On the contrary, sodium acetate has been proven to exert antioxidant activity …

Unraveling the complexity of the impact of physical exercise on male reproductive functions: a review of both sides of a coin

OE Adelowo, BM Akindele, CA Adegbola… - Frontiers in …, 2024 - frontiersin.org
Regular exercise is widely recognized for its numerous physical and mental benefits, but its
effects on male reproductive health are less understood. This review aims to summarize the …

Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction

A Rył, Ż Ciosek, A Szylińska, A Jurewicz… - Biomolecules, 2024 - mdpi.com
Background: Erectile dysfunction (ED) stands out as one of the most prevalent sexual
disorders in men, with its incidence progressively escalating with age. As delineated by the …

Androgens and erectile dysfunction: from androgen deficiency to treatment

Y Wang, R Jiang - Sexual Medicine Reviews, 2024 - academic.oup.com
Introduction Androgens play important roles in regulating the growth and development of the
male reproductive system and maintaining libido and erectile function. The specific …

Lead Decreases Bone Morphogenetic Protein-7 (BMP-7) Expression and Increases Renal Cell Carcinoma Growth in a Sex-Divergent Manner

EA Grunz, H Anderson, RM Ernst, S Price… - International Journal of …, 2024 - mdpi.com
Both tissue and blood lead levels are elevated in renal cell carcinoma (RCC) patients.
These studies assessed the impact of the subchronic lead challenge on the progression of …